Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer’s disease

The degeneration of cholinergic neurons is a prominent feature of Alzheimer’s disease (AD). In animal models of injury and aging, nerve growth factor (NGF) enhances cholinergic cell survival and function, contributing to improved memory. In the presence of AD pathology, however, NGF-related therapeutics have yet to fulfill their regenerative potential. We propose that stimulating the TrkA receptor, without p75NTR activation, is key for therapeutic efficacy. Supporting this hypothesis, the selective TrkA agonist D3 rescued neurotrophin signaling in TgCRND8 mice, whereas NGF, interacting with both TrkA and p75NTR, did not. D3, delivered intravenously and noninvasively to the basal forebrain using MRI-guided focused ultrasound (MRIgFUS)–mediated blood-brain barrier (BBB) permeability activated TrkA-related signaling cascades and enhanced cholinergic neurotransmission. Recent clinical trials support the safety and feasibility of MRIgFUS BBB modulation in AD patients. Neuroprotective agents targeting TrkA, combined with MRIgFUS BBB modulation, represent a promising strategy to counter neurodegeneration in AD. Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by p...

Britain’s Most Wildlife-Friendly Housing Development Chooses Jacksons Acoustic Fencing

Security fencing for all applications, including vertical bar, welded mesh, metal railings, sports fencing, playground fencing and GRP.  Security Rated Fencing is integral to any well-planned perimeter security strategy as it provides the reassurance of tested performance against a range of threats. Jacksons high security fencing and gates deliver integrated perimeter security and access control solutions for a wide variety of sensitive and critical applications. Jacksons beautifully handcrafted fence panels are made with exact attention to ensure the utmost quality and durability for a long service life. Timber and steel automated and manual gates, and guidance on specification, installation and maintenance. Our range of hostile vehicle mitigation products includes PAS 68 bollards, road blockers, speed gates, manual arm barriers and crash fences. Our range of parking control and barriers includes car bars, road blockers, rising arm barriers, swing barriers and turnstiles. Timber fencing for a wide range of commercial applications, from residential developments and public parks to pubs, restaurants, and hospitals. Jacksons Fencing has provided solutions for many applications and...

The U.S. Department of Agriculture has received and will begin reviewing Indiana’s state guidelines for the

The U.S. Department of Agriculture has received and will begin reviewing Indiana’s state guidelines for the legal and regulated production of hemp in the Hoosier state.The Indiana Office of the State Chemist and the Indiana State Department of… As farmers closed out their books on 2019, nearly one third said their farm’s financial performance was worse than projected at the start of last year, according to the Purdue University/CME Group Ag Economy Barometer. The monthly economic… With the start of a new year, Florida-based Cormo USA Inc. says it is looking forward to its first full year of operation in Indiana. Delayed a year from its original plan, Cormo says it will be working with a still undetermined number of Indiana… A Whitley county-based precision machining company has announced a major expansion, due in part to a contract with farm equipment manufacturer John Deere and Co. (NYSE: DE). Impact CNC, a contract computerized numerical control (CNC) manufacturing… The Indiana Farm Bureau says passage of the U.S.-Mexico-Canada Free Trade Agreement is “wonderful news for Hoosier farmers.” The U.S. House of Representatives on Thursday gave bi...

Control4 launches Pakedge online training programme

Control4 has launched a Pakedge Certified Network Administrator (PCNA) programme. PCNA is an online training experience that employs a unique blend of comprehensive online coursework with hands-on practical learning using Pakedge networking gear to provide dealers and technicians the networking knowledge they need to design, install, and manage wired and wireless IP networks. The PCNA course curriculum combines interactive coursework, online instructional office hours, and an online certification exam to ensure networking competency for the global Control4 and Pakedge dealer base. Practical, hands-on training for networking has been lacking throughout the connected home and custom install industry. Technicians learn mainly through trial and error. The result is that the networking foundation of many homes and small businesses tends to be the root cause of chronic issues — caused more so by the lack of best-practice knowledge than through defective or failed equipment. “Reliable and consistent network design is foundational to a responsive and stable connected home, and it’s pivotal to our dealers’ success and their customers’ satisfaction. Yet today, over 30 per cent of support ...

Gold Nanoparticles Market Insights by Size, Status and Forecast 2026

The global market for gold nanoparticles is highly competitive and is considered as consolidated in nature, owing to the presence of a few local and global players operating worldwide, states a new market intelligence study by Transparency Market Research. The leading players in the market are competing on the basis of product quality, distribution network, and creative developments. The key players are focusing on the research and development activities and technological advancements, which are projected to offer lucrative growth opportunities for the market players in the next few years. In addition to this, the increasing number of mergers and acquisitions and collaborations are estimated to enhance the overall competitive environment of the market in the next few years. Some of the key players operating in the gold nanoparticles market across the globe are Johnson Matthey Plc, Cline Scientific, Innova Biosciences, Meliorum Technologies, Inc., Sigma Aldrich, Nanocomposix Inc., Cytodiagnostics, Nanopartz Inc., TANAKA, and BBI Solutions. The global gold nanoparticles market is highly competitive and is considered as consolidated in nature, owing to the presence of a few local a...

Desktop Metal launches 316L stainless steel for metal 3D printing

Desktop Metal launched 316L stainless steel for the Studio System, an office friendly metal 3D printing system for prototyping and low volume production. A fully austenitic steel known for its corrosion resistance and excellent mechanical properties at extreme temperatures, 316L is well-suited for applications in demanding industrial environments, including salt water in marine applications, caustic cleaners found in food processing environments, and chemicals in pharmaceutical manufacturing. “The addition of 316L enables engineers to print metal parts for a range of applications, including engine parts, laboratory equipment, pulp and paper manufacturing, medical devices, chemical and petrochemical processing, kitchen appliances, jewelry and even cryogenic tools and equipment,” said Ric Fulop, CEO and co-founder of Desktop Metal. Early applications of 316L parts printed with the Studio System confirm the diverse and promising results across multiple industries: Combustion fuel nozzle for marine tankers The UHT Atomizer, manufactured by John Zink Hamworthy Combustion, is a fuel oil atomiser for use with atomising medium such as steam or air. It is typically installed in an HXG ma...

Surgi Med introduces new prostate treatment | Local News

Managing Director of Surgi Med Clinic Company Limited Anirudh Mahabir and the Head of Radiology Stephen Persad with the 120W Holminum Laser. Managing Director of Surgi Med Clinic Company Limited Anirudh Mahabir and the Head of Radiology Stephen Persad with the 120W Holminum Laser. With so many advancements in medicine, new techniques and technology have made surgery now less invasive. Urology is one of the areas that is reaping the benefits. A man’s body does not have to be surgically cut open to do prostate surgery anymore, thanks to a medical device called the 120W Holmium Laser. Managing Director of Surgi Med Clinic Company Limited in San Fernando, Anirudh Mahabir says the laser is the first of its kind in the Caribbean and Latin America. Stone dusting is a common medical term used to describe how stones within the body are treated. The holminum laser provides a wide range of settings such as pulse energy, pulse frequency, and pulse width. In stone dusting, these settings are utilized to break stones into microscopic fragments, which are then removed from the body. Mahabir said, “It is the most powerful laser in the world for urology. It is used to get rid of stones in the ki...

Ferry terminal project $10M over budget – News – capecodtimes.com

WOODS HOLE — The long-term project to reconstruct the ferry terminal in Woods Hole is chugging along, but not without exceeding its $60 million budget by $10 million. Woods Hole, Martha’s Vineyard and Nantucket Steamship Authority General Manager Robert Davis was giving updates on the project at a board of governors meeting Tuesday when board member Moira Tierney began asking about the budget. “Overall is it fair to say, am I reading it correctly, that the change orders and increased cost and the increased accounting fees and all the rest of it, has added a $10 million increase to the project?” Tierney asked. Tierney was concerned about the budget, as the authority cannot afford to build a new shipping vessel without seeking additional funding, which will not be easy, she said. One board member said the Steamship Authority was close to “falling off the edge” of its project budget.  After an open house at the authority’s administrative offices Wednesday, Davis said officials underestimated the budget, but the overspending was not unexpected. “Most of it is not a surprise,” he said. “There’s another 4 million there that we knew was coming. We’re doing it as each phase goes a...